Weber was born in Seara, Santa Catarina, Brazil. She is of German descent. Weber was discovered when a photographer took pictures of her and sent them to agencies in São Paulo.
Weber’s debut on the international fashion scene was at the Spring 2006 New York Fashion Week shows. She walked for Tommy Hilfiger and Jenni Kayne. She also walked in Paris on her first season. Her print career started in Brazil. She worked for Brazilian magazines like their editions of Vogue and Marie Claire. Her first big season, she opened shows for Shiatzy Chen, Daks, Balenciaga, and Requiem. Also walking for Calvin Klein, Marc Jacobs, and Proenza Schouler.
Weber has walked the international runways many times, and for renowned fashion houses like Balenciaga, Narciso Rodriguez, and Calvin Klein.
Magazine work has also put Weber on the map, appearing in magazines like Vogue, Harper’s Bazaar, and i-D.
Weber’s face has been used as the face of many campaigns, like D&G, M for Missoni, H & M Divided, and Moschino Cheap and Chic.
Weber appeared in Tom Ford’s film A Single Man playing the role of a student named Lois.